Vacuolation, proliferation and neoplasia in the liver of Boston Harbor Winter Flounder (Pseudopleuronectes americanus)

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by
Woods Hole Oceanographic Institution , Woods Hole, Mass
Winter flounder., L
Statementby Michael John Moore.
SeriesWHOI -- 91-28., WHOI (Series) -- 91-28.
ContributionsWoods Hole Oceanographic Institution.
The Physical Object
Pagination266 p. :
ID Numbers
Open LibraryOL15173740M

Neoplasia has been found in the livers of bottom-feeding fish taken from heavily contaminated freshwater and marine habitats. This study examined the progressive development and ultimate diversity of liver neoplasia in winter flounder (Pseudopleuronectes americanus) from Deer Island Flats, Boston Harbor, MA., U.S.A., and encompassed histopathology, ultrastructural pathology.

Liver lesions including neoplasia and hydropic vacuolation have been described in winter flounder (Pleuronectes americanus) from sites in Boston Harbor, and were highly prevalent near the Deer. Winter flounder were captured by scuba divers from an area adjacent to a sulfite pulp and paper mill and from a reference site and the tissues examined for lesions.

Severe hyperplasia of the gills, focal vacuolation in the liver, and multifocal hemosiderosis in the spleen and liver were most pronounced in large, adult fish collected near the by: Winter flounder (Pleuronectes americanus) from Boston Harbor, Massachusett, undergo a progressive series of hepatic changes involving hydropic vacuolation of epithelial cells, biliary hyperplasia, and hepatocellular and cholangiocellular neoplasia.

Severely affected fish often exhibit grossly visible by: 8. In 12% of the adult winter flounder in Boston Harbor exhibited hepatic neoplasms and up to 80% had hepatic hydropic vacuolation (HV).

Tumor prevalence fell to % and HV to. Hepatic changes that include hepatocellular and cholangiocellular neoplasia are prevalent in adult winter flounder from Boston Harbor, Massachusetts.t The syndrome includes local and diffuse aggregations of abnormally vacuolated hepatocytes and cholangiocytes, previously described as hepatotoxic cells,t which form the predominant non- neoplastic lesion by:   For both species, hydropic vacuolation of biliary epithelial cells was the most prevalent liver lesion detected and was statistically associated with sediment and tissue concentrations of PAHs or their metabolites, PCBs, DDTs, chlordanes and by: Liver lesions including neoplasia and hydropic vacuolation have been described in winter flounder (Pleuronectes americanus) from sites in Boston Harbor, and were highly prevalent near the Deer Island sewage outfall.

A marked decline in prevalence of neoplasia has been seen over the period to in fish from near the Deer Island by: Vacuolation, proliferation and neoplasia in the liver of Boston Harbor winter flounder (Pseudopleuronectes americanus).

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PhD Dissertation, Massachusetts Institute of Technology, Woods Hole Oceanographic Institution. Woods Hole, by:   Liver neoplasms, including hepatocellular and cholangiocellular tumors, commonly occur in winter flounder (Pleuronectes americanus) caught from some chemically contaminated areas such as Boston Harbor.

Hydropically vacuolated cells, very often associated with neoplasia in winter flounder liver, appear to represent the first cellular abnormality in animals that later develop frank by: In this study, ODC was utilized as a biochemical indicator for cell proliferation to characterize proliferative hepatic lesions in 24 Boston Harbor winter flounder (Pleuronectes americanus).

Cellular vacuolation, the commonest epithelial change defining disease, was present in 12/24 by: 3. Moore Michael John,“Vacuolation, proliferation and neoplasia in the liver of Boston Harbor winter flounder (Pseudopleuronecte americanus)”, Woods Hole Scientific Community.

Livers of a natural population of winter flounder from a contaminated site in Boston Harbor were examined for the presence of oncogenes by transfection of DNA into NIH 3T3 mouse fibroblasts. winter flounder taken from the heavily polluted Boston Harbor.

In 2- to 3-year-old fish, these cells were preductular biliary epithelia located in the center of a hepatic tubule. Moore MJ () Vacuolation, proliferation and neoplasia in the liver of Boston Harbor winter flounder (Pseudopleuronectes americanus).

Ph.D. thesis. Woods Hole Oceanographic Institution, Massachusetts Institute of Technology, Cambridge, Massachusetts. Woods Hole Oceanographic InstituteppCited by:   Primary neoplasms of the liver are composed of cells that resemble the normal constituent cells of the liver. Hepatocellular carcinoma, in which the tumor cells resemble hepatocytes, is Cited by: Vacuolation, proliferation and neoplasia in the liver of Boston Harbor winter flounder (Pseudopleuronectes americanus).

Boston MA. Moore, M., and Stegeman, J. 2 vs 4 cycle outboard motors: aromatic hydrocarbons and biological. Vacuolation, Proliferation and Neoplasia in the Liver of Boston Harbor Winter Flounder (Pseudopleuronectes americanus). Ph.D. Dissertation, MIT/WHOI Joint Program in Biological Oceanography.

Ph.D. Dissertation, MIT/WHOI Joint Program in Biological Oceanography.

Details Vacuolation, proliferation and neoplasia in the liver of Boston Harbor Winter Flounder (Pseudopleuronectes americanus) PDF

Neoplasms and nonneoplastic liver lesions in winter flounder, Pseudopleuronectes americanus, from Boston Harbor, Massachusetts. Environ Health Perspect (). Overview ofstudies on liver carcinogenesis in English sole from Puget Sound; evidence for a xenobiotic chemical etiology I: Pathology and epizootiology.

centrotubular hydropic vacuolation (CHV) in winter flounder from Boston Harbor in the late s was one of the findings that contributed to the concern about the ecological health of the Harbor. For example, inover 75% of flounder collected in Boston Harbor showed evidence of disease in liver.

Vacuolation proliferation and neoplasia in the liver of Boston Harbor winter flounder Pseudopleuronectes americanus Dafis-moore StudyBlue. Choose two kinds of inequality. Davis—Moore hypothesis – Wikipedia The Davis—Moore hypothesis, sometimes referred to as the Davis—Moore theory, is a central claim within the structural functionalist.

Diagnostic criteria for proliferative hepatic lesions in brown bullhead Ameiurus nebulosus. plastic liver lesions in winter flounder, from Boston Harbor.

centrotubular hydropic vacuolation) in winter flounder from Boston Harbor in the late s was one of the findings that contributed to the concern about the ecological health of the Harbor. For example, inover 75% of flounder collected in Boston Harbor showed evidence of disease in liver tissue.

Description Vacuolation, proliferation and neoplasia in the liver of Boston Harbor Winter Flounder (Pseudopleuronectes americanus) EPUB

Moore MJ () Vacuolation, proliferation, and neoplasia in the liver of Boston Harbor winter flounder (Pseudopleuronectes americanus). PhD Dissertation. MIT-Woods Hole Oceanogr Inst, Woods Hole, MA, pp.

Google ScholarCited by: Flounder Monitoring Report November Figure Temporal comparison of fin rot prevalence (%) in winter flounder by station. Liver Lesion Prevalence The prevalence (% of individuals) of liver lesions in winter flounder from each of the four stations sampled in is presented in Table   Swelling with nonlipid cytoplasmic vacuolation of diffusely distributed hepatocytes is seen consistently after mild acute and subacute liver injury.

Several lines of evidence point to the possibility that this change may reflect a cellular adaptation beneficial to the host, rather than a degenerative change. The nature and significance of this morphological manifestation were tested in Cited by: Winter flounder (Pseudopleuronectes americanus) were collected from four locations in Boston Harbor and the Bays (Figure ) to obtain specimens for age, weight, and length determination, gross examination of health, and histology of livers.

Pathogenesis of liver neoplasia in English sole and winter flounder. SETAC, 12th Annual Meeting, Seattle WA Nov 3 to 7.

Moore, M. and Stegeman, J. Bromodeoxyuridine uptake, cytochrome PA expression and presumptive oval cells in liver of winter flounder (Pleuronectes americanus), exposed to dietary benzo(a)pyrene and chlordane. of the hepatocyte vacuolation (the left and right lateral lobes), liver weight, and liver to body weight ratio in SD rats after euthanasia with CO2.

Vacuolation Liver weight Liver to body weight (severity) (grams) (ratio, %) Postmortem interval (minute) Male Female Male Female Male Female Nonfasted 0 +± 5 ++ ± 4. NOAA-NWFSC Tech Memo Bioindicators of Contaminant Exposure in Winter Flounder Cytological study of vacuolated cells and other aberrant hepatocytes in winter flounder from Boston Harbor.

Cancer Res. Breslow, D., and N. Day. Vacuolation, proliferation and neoplasia in the liver of Boston Harbor winter. The nature and significance of liver cell vacuolation following hepatocellular injury - an analysis based on observations on rats rendered tolerant to hepatotoxic damage Received: 12 October /Accepted: 29 March Abstract Swelling with nonlipid cytoplasmic vacuola.Collier, T.K., and M.S.

Myers. Monitoring the effectiveness of sediment capping in the East Harbor Operable Unit of Eagle Harbor, Puget Sound, Washington. Final Report for interagency agreement between the Office of Puget Sound, U.S. EPA Region 10 and the Environmental Conservation Division, NWFSC, NMFS, NOAA.

May, The nature and significance of liver cell vacuolation following hepatocellular injury--an analysis based on observations on rats rendered tolerant to hepatotoxic damage. Nayak NC(1), Sathar SA, Mughal S, Duttagupta S, Mathur M, Chopra P.

Author information: (1)Department of Pathology, Faculty of Medicine, Kuwait University, Safat, by: